Production of extracellular DNA in a natural Bacillus subtilis strain


Extracellular DNA (eDNA) is called free genetic material in the environment and its presence in sediments and aquatic environments is widely distributed. The origin of the eDNA is mainly bacterial and numerous studies have identified that the eDNA can influence the establishment and exchange of genetic material in microbial communities.
In this study, it has been studied. identified that a natural strain & nbsp; of Bacillus subtilis secretes numerous identical copies of its genome into the medium and there is no rupture of the membrane involved, so the existence of an active secretion of eDNA is proposed. It has also been shown that this production is regulated by genes involved in the phenomenon of "competition", which is the ability to capture and integrate into the genome of exogenous DNA bacteria. Therefore, there is a coordination that allows the release of genetic material to the environment at the moment when other bacteria in the population are able to capture it. Finally, it has been demonstrated that the B. subtilis eDNA is indeed susceptible to being captured and integrated into the genome of competent bacteria, so it is proposed that the main function in these communities is horizontal gene transfer. This is the mechanism that bacteria use to induce a genetic exchange, which, for example, induces resistance to antibiotics in pathogenic bacteria.
Therefore, this is a very important mechanism to understand how microbial communities evolve.


Fuente: UCC-CAB

Fecha: 2012-12-17


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